Can I read Poly(lactide-co-glycolide) Decomposition Kinetics in Vivo and in Vitro on EtoBox?

Poly(lactide-co-glycolide) Decomposition Kinetics in Vivo and in Vitro by Richard A. Kenley; Maryann Ott Lee; T. Randolph Mahoney; Lynda M. Sanders is a Materials Science article available to read on EtoBox.

What is Poly(lactide-co-glycolide) Decomposition Kinetics in Vivo and in Vitro about?

We examined ten d,l-lactidelglycolide copolymers representing a range of monomer ratios and molecular weights. We characterized the molecular weight distributions by intrinsic viscosity measurements (in two solvents) and by size-exclusion chromatography (SEC) using the "universal calibration" procedure. In tetrahydrofuran, the copolymers obey the following Mark-Houwink relationship: [?ITHF = (1.07 X 104)M0.761. In hexafluoro-2-propanol they obey [?Imp = (1.67 X 10-4)M0.794. Using a 5050 1actide:glycolide copolymer, we prepared cylindrical samples and incubated them for timed intervals in pH 4.5-7.4 aqueous buffers at 37 "C. We also implanted parallel samples subcutaneously in rats. We then monitored the time-dependent changes in sample total weight (TW) and molecular weight (MW). TW and MW profiles were superimposable for all samples, demonstrating pH-independent hydrolysis in vitro and equivalent in vivo versus in vitro copolymer degradation rates. TW loss lagged behind MW loss, indicating copolymer erosion via internal (versus surface) hydrolysis and dissolution. The copolymer MW loss rates adhered well to a pseudo-first-order kinetic model where the number of chain cleavages ( X

Who reads Poly(lactide-co-glycolide) Decomposition Kinetics in Vivo and in Vitro?

Author

Richard A. Kenley; Maryann Ott Lee; T. Randolph Mahoney; Lynda M. Sanders

Published

1987

Language

EN

Field

Materials Science (Physical Sciences)