About this Neuroscience article

Modulation of Amygdala Reactivity Following Rapidly Acting Interventions for Major Depression by Joana R. A. Loureiro; Amber Leaver; Megha Vasavada; Ashish K. Sahib; Antoni Kubicki; Shantanu Joshi; Roger P. Woods; Benjamin Wade; Eliza Congdon; Randall Espinoza; Katherine L. Narr is a Neuroscience article available to read on EtoBox.

## Abstract Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting antidepressant effects in patients with major depressive disorder unresponsive to standard treatments, yet their specific impact on emotion processing is unknown. Here, we examined the neural underpinnings of emotion processing within and across patients (__N__ = 44) receiving either ECT (__N__ = 17, mean age: 36.8, 11.0 __SD__) or repeated subanesthetic (0.5 mg/kg) intravenous ketamine therapy (__N__ = 27, mean age: 37.3, 10.8 __SD__) using a naturalistic study design. MRI and clinical data were collected before (TP1) and after treatment (TP2); healthy controls (__N__ = 31, mean age: 34.5, 13.5 __SD__) completed one MRI session (TP1). An fMRI face‐matching task probed negative‐ and positive‐valence systems. Whole‐brain analysis, comparing neurofunctional changes within and across treatment groups, targeted brain regions involved in emotional facial processing, and included regions‐of‐interest analysis of amygdala responsivity. Main findings revealed a decrease in amygdalar reactivity after both ECT and ketamine for positive and negative emotional face processing (__p__ < .05 family wise‐e

Author

Joana R. A. Loureiro; Amber Leaver; Megha Vasavada; Ashish K. Sahib; Antoni Kubicki; Shantanu Joshi; Roger P. Woods; Benjamin Wade; Eliza Congdon; Randall Espinoza; Katherine L. Narr

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)