Can I read Protective Role of Silibinin Against Myocardial Ischemia/reperfusion Injury-induced Cardiac Dysfunction on EtoBox?

Protective Role of Silibinin Against Myocardial Ischemia/reperfusion Injury-induced Cardiac Dysfunction by Chen, Yi-He; Lin, Hui; Wang, Qian; Hou, Jian-Wen; Mao, Zhi-Jie; Li, Yi-Gang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Protective Role of Silibinin Against Myocardial Ischemia/reperfusion Injury-induced Cardiac Dysfunction about?

Silibinin is a traditional medicine and utilized for liver protection with antioxidant, anti-inflammation and anti-apoptosis properties. However, its role in myocardial I/R injury and the mechanism involved is currently unknown. In the present study, Silibinin treatment improves cardiac function and limits infarct size, and subsequently inhibits fibrotic remodeling in mice with myocardial I/R injury. Mechanistically, silibinin reduces cardiomyocytes apoptosis, attenuates mitochondrial impairment and endoplasmic reticulum (ER) stress, alleviates ROS generation, neutrophil infiltration and cytokines release. Consistently, silibinin prevents H9C2 cells from hypoxia/reperfusion-induced cell death, oxidative stress and inflammation __in vitro__. Furthermore, H9C2 cells treated with silibinin blocks NF-κB signaling activation by inhibiting IKKα phosphorylation, IκBα degradation and p65 NF-κB nuclear translocation during hypoxia/ reperfusion. In addition, silibinin plus BAY 11-7082 (a selected NF-κB inhibitor) do not provide incremental benefits in improving myocytes apoptosis, oxidative stress and inflammation in comparison with NF-κB signaling inhibition only. Thus, silibinin-mediated c

Who reads Protective Role of Silibinin Against Myocardial Ischemia/reperfusion Injury-induced Cardiac Dysfunction?

Author

Chen, Yi-He; Lin, Hui; Wang, Qian; Hou, Jian-Wen; Mao, Zhi-Jie; Li, Yi-Gang

Publisher

Ivyspring International Publisher; Bluehaven (N.S.W.): Ivyspring International, 2004- (ISSN 1449-2288)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)