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The Ageing Epigenome and Its Rejuvenation by Weiqi Zhang; Jing Qu; Guang-Hui Liu; Juan Carlos Izpisua Belmonte is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Ageing Epigenome and Its Rejuvenation about?

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several 'rejuvenating' interventions have been proposed to delay ageing and the onset of age-associated decline and disease to extend healthspan and lifespan. These interventions include metabolic manipulation, partial reprogramming, heterochronic parabiosis, pharmaceutical administration and senescent cell ablation. As the ageing process is associated with altered epigenetic mechanisms of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, and non-coding RNAs, the manipulation of these mechanisms is central to the effectiveness of age-delaying interventions. This Review discusses the epigenetic changes that occur during ageing and the rapidly increasing knowledge of how these epigenetic mechanisms have an effect on healthspan and lifespan extension, and outlines questions to guide future research on interventions to rejuvenate the epigenome and delay ageing processes.

Who reads The Ageing Epigenome and Its Rejuvenation?

Author

Weiqi Zhang; Jing Qu; Guang-Hui Liu; Juan Carlos Izpisua Belmonte

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)