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Can I read Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer on EtoBox?
Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer by Athina Markou; Yu Liang; Evi Lianidou is a Medicine article available to read on EtoBox.
What is Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer about?
Non-small cell lung carcinomas (NSCLC) account for about 80% of lung cancers and their remarkable heterogeneity manifests in histology, pathogenesis, prognosis, and response to treatments. Recent advances in molecular characterization help stratifying NSCLC patients for their potential benefit from targeting therapies. However, the fundamental mechanisms underlying the tumoral heterogeneity remain poorly understood. Expression profiling of many microRNAs (miRNAs) in various normal and disease tissues demonstrated unique spatial and temporal expression patterns and some miRNAs have been functionally characterized as oncogenes or tumor suppressor genes. Genome-wide screening identified specific miRNA expression signatures associated with clinical outcome of NSCLC patients. A group of miRNAs that has enriched expression in normal lung was found down regulated in NSCLC and may function as tumor suppressor genes. In this review we: a) summarize the current understanding of the critical role that miRNAs play in normal cell functions and in disease biology especially in lung cancer tumorigenesis, b) highlight their potential as biomarkers for lung cancer risk stratification, outcome predi
Who reads Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Athina Markou; Yu Liang; Evi Lianidou
- Publisher
- Walter de Gruyter GmbH
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)