Can I read P53 Protein Expression in Lymphomas and Reactive Lymphoid Tissue on EtoBox?

P53 Protein Expression in Lymphomas and Reactive Lymphoid Tissue by Raquel Villuendas; Miguel A. Piris; Juan L. Orradre; Manuela Mollejo; Patrocinio Algara; Lydia Sanchez; Juan C. Martinez; Pedro Martinez is a Medicine article available to read on EtoBox.

What is P53 Protein Expression in Lymphomas and Reactive Lymphoid Tissue about?

## Abstract P53 is a tumour suppressor gene, located in the short arm of chromosome 17, which encodes for a nuclear protein involved in the control of cellular growth, regulating the entry of the cell into the S‐phase. P53 mutations have been identified in a progressively increasing number of human malignancies. Nuclear p53 protein is usually present in non‐tumour cells in minute concentrations, due to its short half‐life. In contrast, tumours with p53 mRNA mutations show a higher nuclear protein concentration, detectable by immunohistological techniques, due to stabilization by complexing with other proteins such as heat‐shock protein or wild‐type p53 protein. Leveis of nuclear p53 protein detected by immunohistochemistry with the monoclonal antibody PAb 1801 were measured with the aid of an image analysis system in 83 non‐Hodgkin's lymphomas (NHLs) and 13 cases of Hodgkin's disease, as well as in 14 cases of normal thymus, reactive tonsils, and lymphadenitis. High levels of p53 protein (>5 per cent of the cells) were present only in high‐grade lymphomas (in the proportion 13/55), with a peak incidence in Burkitt's lymphoma (5/8 cases). Lower levels (<5 per cent) of p53 protein we

Who reads P53 Protein Expression in Lymphomas and Reactive Lymphoid Tissue?

Author

Raquel Villuendas; Miguel A. Piris; Juan L. Orradre; Manuela Mollejo; Patrocinio Algara; Lydia Sanchez; Juan C. Martinez; Pedro Martinez

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1992

Language

EN

Field

Medicine (Health Sciences)