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Investigations on the Predictability of the Formation of Glassy Solid Solutions of Drugs in Sugar Alcohols by M Langer; M Höltje; N.A Urbanetz; B Brandt; H.-D Höltje; B.C Lippold is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Investigations on the Predictability of the Formation of Glassy Solid Solutions of Drugs in Sugar Alcohols about?

A prerequisite for the formation of glassy solid solutions prepared by the melting method is the miscibility of the respective drug and the carrier in the molten state. As could be shown experimentally, all investigated drug/sugar alcohol combinations miscible in the molten state form to some extent glassy solid solutions, dependent on their tendency to recrystallize during preparation. Therefore, the present study focuses on the evaluation of factors that govern the miscibility of molten drugs and sugar alcohols as carriers. In this context, solubility parameters are discussed as a means of predicting miscibility in comparison to a new approach, using calculated interaction parameters derived from molecular dynamics (MD) studies. There is evidence that a Coulomb interaction term C(SR), comprising short-range electrostatic interactions and hydrogen bonding energy is essential for the miscibility of drug and carrier in the molten state. To relate C(SR) to the molecular volume, a non-dimensional parameter P(i) is defined. For this parameter, a limiting value for miscibility exists. Contrary, calculated solubility parameter differences between drug and sugar alcohol in the range of 8-

Who reads Investigations on the Predictability of the Formation of Glassy Solid Solutions of Drugs in Sugar Alcohols?

Author

M Langer; M Höltje; N.A Urbanetz; B Brandt; H.-D Höltje; B.C Lippold

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2003

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)