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Sample Pooling to Expedite Bioanalysis and Pharmacokinetic Research by Be-Sheng Kuo; Ted Van Noord; M.Rose Feng; D.Scott Wright is a Chemistry article available to read on EtoBox.
What is Sample Pooling to Expedite Bioanalysis and Pharmacokinetic Research about?
In the progression from drug discovery to development, not only pharmacokinetic (PK) characterization needed for lead compound selection often becomes a rate-limiting step, but also high volume of routine sample analysis ensued from numerous required biodisposition studies for the lead compounds and their back-ups often place a burdensome hurdle to the throughput of IND and NDA development phases. Higher throughput of PK screening via cocktail dosing has been reported to accelerate PK screening in the discovery phase. However, concerns on drug-drug interactions and other limitations associated with the cocktail M-in-One dosing (multiple compounds per dose per animal) has prompted the present investigation of sample pooling alongside One-in-One dosing strategy (one compound per dose per animal) as an alternative to the cocktail dosing approach. Using traditional HPLC for bioanalysis as an example, the present study illustrate the concept and usefulness of sample pooling that could facilitate the throughput of PK screening and characterization in both discovery and development phases. Six proprietary dopamine D4 receptor antagonist preleads representing three different chemical class
Who reads Sample Pooling to Expedite Bioanalysis and Pharmacokinetic Research?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Be-Sheng Kuo; Ted Van Noord; M.Rose Feng; D.Scott Wright
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 1998
- Language
- EN
- Field
- Chemistry (Physical Sciences)