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Can I read Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation on EtoBox?
Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation by Thomas Fabre; Alexander M. S. Barron; Stephen M. Christensen; Shoh Asano; Kathryn Bound; Matthew P. Lech; Marc H. Wadsworth; Xiao Chen; Chang Wang; Ju Wang; James McMahon; Franklin Schlerman; Alexis White; Kellie M. Kravarik; Andrew J. Fisher; Lee A. Borthwick; Kevin M. Hart; Neil C. Henderson; Thomas A. Wynn; Ken Dower is a Immunology and Microbiology article available to read on EtoBox.
What is Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation about?
Macrophages are central orchestrators of the tissue response to injury, with distinct macrophage activation states playing key roles in fibrosis progression and resolution. Identifying key macrophage populations found in human fibrotic tissues could lead to new treatments for fibrosis. Here, we used human liver and lung single-cell RNA sequencing datasets to identify a subset of CD9 + TREM2 + macrophages that express SPP1 , GPNMB , FABP5 , and CD63 . In both human and murine hepatic and pulmonary fibrosis, these macrophages were enriched at the outside edges of scarring and adjacent to activated mesenchymal cells. Neutrophils expressing MMP9, which participates in the activation of TGF-β1, and the type 3 cytokines GM-CSF and IL-17A coclustered with these macrophages. In vitro, GM-CSF, IL-17A, and TGF-β1 drive the differentiation of human monocytes into macrophages expressing scar-associated markers. Such differentiated cells could degrade collagen IV but not collagen I and promote TGF-β1–induced collagen I deposition by activated mesenchymal cells. In murine models blocking GM-CSF, IL-17A or TGF-β1 reduced scar-associated macrophage expansion and hepatic or pulmonary fibrosis. Our
Who reads Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Thomas Fabre; Alexander M. S. Barron; Stephen M. Christensen; Shoh Asano; Kathryn Bound; Matthew P. Lech; Marc H. Wadsworth; Xiao Chen; Chang Wang; Ju Wang; James McMahon; Franklin Schlerman; Alexis White; Kellie M. Kravarik; Andrew J. Fisher; Lee A. Borthwick; Kevin M. Hart; Neil C. Henderson; Thomas A. Wynn; Ken Dower
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 2023
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)