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Mechanisms of Hebbian-like Plasticity in the Ventral Premotor - Primary Motor Network by Andrea Casarotto; Elisa Dolfini; Pasquale Cardellicchio; Luciano Fadiga; Alessandro D'Ausilio; Giacomo Koch is a Neuroscience article available to read on EtoBox.

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Many people suffer from cognitive decline caused by hippocampal dysfunction due to neurodegeneration, yet there is no effective medical intervention available. We propose a novel minimally invasive method to stimulate brain regions involved in memory by means of epicranial stimulation (ECS). Three adult rhesus monkeys were implanted bilaterally with custom-built platinum stimulation electrodes on the temporal skull. We investigated the effects of ECS on behavior during a non-navigational spatial memory task, in which the animal had to remember the locations of two shapes presented on a touch screen. In one monkey, we applied ECS before and during presentation of half of the patterns while the monkey performed the task. We observed a significant memory improvement (percent correct) for the stimulated patterns with 3 mA 40 Hz ECS, whereas stimulation at 10 Hz and 3 mA induced a significant decrease in performance for the stimulated patterns. Single-cell recordings in the lateral sulcus showed a significant difference between 10 and 40 Hz ECS as the average firing rate increased significantly more after 40 Hz than after 10 Hz ECS. To chart the effects of ECS at the network level, we p

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Author

Andrea Casarotto; Elisa Dolfini; Pasquale Cardellicchio; Luciano Fadiga; Alessandro D'Ausilio; Giacomo Koch

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)