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Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana by Suvi Torniainen; M Iqbal Parker; Ville Holmberg; Elisa Lahtela; Collet Dandara; Irma Jarvela is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract ## Background Lactase non-persistence is a condition where lactase activity is decreased in the intestinal wall after weaning. In European derived populations a single nucleotide polymorphism (SNP) C/T~-13910~ residing 13.9 kb upstream from the lactase gene has been shown to define lactase activity, and several other single nucleotide polymorphisms (G/C~-14010~ T/G~-13915~, C/G~-13907~ and T/C~-13913~) in the same region have been identified in African and Middle East populations. ## Results The T~-13910~ allele most common in European populations was present in 21.8% mixed ancestry (N = 62) individuals and it was absent in the Xhosa (N = 109) and Ghana (N = 196) subjects. Five other substitutions were also found in the region covering the previously reported variants in African and Middle East populations. These included the G/C~-14010~ variant common in Kenyan and Tanzanian populations, which was present in 12.8% of Xhosa population and in 8.1% of mixed ancestry subjects. Two novel substitutions (C/T~-14091~ and A/C~-14176~) and one previously reported substitution G/A~-13937~ (rs4988234) were less common and present only in the Xhosa population. One novel substitutio

Who reads Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana?

Author

Suvi Torniainen; M Iqbal Parker; Ville Holmberg; Elisa Lahtela; Collet Dandara; Irma Jarvela

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2156)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)