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Can I read Escin Sodium Induces Apoptosis of Human Acute Leukemia Jurkat T Cells on EtoBox?
Escin Sodium Induces Apoptosis of Human Acute Leukemia Jurkat T Cells by Zhenzhen Zhang; Jian Gao; Xueting Cai; Youlong Zhao; Yafei Wang; Wuguang Lu; Zhenhua Gu; Shuangquan Zhang; Peng Cao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Escin Sodium Induces Apoptosis of Human Acute Leukemia Jurkat T Cells about?
Escin sodium has been used in the clinic as an antioedematous, antiexudative and vasoprotective agent for many years and has shown excellent tolerability. However, little is known about its anticancer activity. This is a report for the first time that escin sodium exerts a cytotoxic effect on human acute leukemia Jurkat T cells via the induction of apoptosis rather than cell cycle arrest. Escin sodium activated the initiator caspase‐8, ‐9, and the effector caspase‐3, degraded poly (ADP‐ribose) polymerase (PARP) and attenuated the expression of Bcl‐2. In addition, escin sodium inhibited the growth of cancer cells in a selective manner with Jurkat cells most sensitive to it. Taken together, the data show that escin sodium possesses potent apoptogenic activity toward human acute leukemia Jurkat T cells. Copyright © 2011 John Wiley & Sons, Ltd.
Who reads Escin Sodium Induces Apoptosis of Human Acute Leukemia Jurkat T Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhenzhen Zhang; Jian Gao; Xueting Cai; Youlong Zhao; Yafei Wang; Wuguang Lu; Zhenhua Gu; Shuangquan Zhang; Peng Cao
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)