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Computational insights into the formation and nature of the sulfilimine bond in collagen-IV† by Anupom Roy; Taqred H. Alnakhli; James W. Gauld is a Materials Science article available to read on EtoBox.
What is Computational insights into the formation and nature of the sulfilimine bond in collagen-IV† about?
Collagen IV is essential component of basement membrane in the tissues. It provides proper cellular structure by the formation of sulfilimine bond (S Created by potrace 1.16, written by Peter Selinger 2001-2019 ]]> N) between methionine and lysine or hydroxylysine (cross-links) residues which can be formed with or without post-translational modification. The sulfilimine bond has critical roles in tissue development and human diseases. Peroxidasin, a basement membrane peroxidase, generates reactive halogen species including hypobromous (HOBr) acid and hypochlorous (HOCl) acid which help to form halosulfonium or haloamine. The sulfilamine bond can be formed either by the formation of halosulfonium or by the formation of halomine. The aim of the study is the investigation of the formation of sulfilimine bond and its nature in collagen IV using multi-scale approach that included MD, QM-cluster, systematic series of small models, and NBO analysis. These results suggest that sulfilimine bond can be formed either __via__ brominated/chlorinated halosulfonium or haloamine pathway. The results of systematic series of small model indicate that the formation of sulfilimine complex from halo
Who reads Computational insights into the formation and nature of the sulfilimine bond in collagen-IV†?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Anupom Roy; Taqred H. Alnakhli; James W. Gauld
- Published
- 2022
- Language
- EN
- Field
- Materials Science (Physical Sciences)