Can I read From in Vivo to in Vitro: Exploring the Key Molecular and Cellular Aspects of Human Female Gametogenesis on EtoBox?

From in Vivo to in Vitro: Exploring the Key Molecular and Cellular Aspects of Human Female Gametogenesis by Sarah Abreu Coxir; Guilherme Mattos Jardim Costa; Camilla Fernandes dos Santos; Raquel de Lima Leite Soares Alvarenga; Samyra Maria dos Santos Nassif Lacerda is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is From in Vivo to in Vitro: Exploring the Key Molecular and Cellular Aspects of Human Female Gametogenesis about?

Human oogenesis is a highly complex and not yet fully understood process due to ethical and technological barriers that limit studies in the field. In this context, replicating female gametogenesis in vitro would not only provide a solution for some infertility problems, but also be an excellent study model to better understand the biological mechanisms that determine the formation of the female germline. In this review, we explore the main cellular and molecular aspects involved in human oogenesis and folliculogenesis in vivo, from the specification of primordial germ cells (PGCs) to the formation of the mature oocyte. We also sought to describe the important bidirectional relationship between the germ cell and the follicular somatic cells. Finally, we address the main advances and different methodologies used in the search for obtaining cells of the female germline in vitro.

Who reads From in Vivo to in Vitro: Exploring the Key Molecular and Cellular Aspects of Human Female Gametogenesis?

Author

Sarah Abreu Coxir; Guilherme Mattos Jardim Costa; Camilla Fernandes dos Santos; Raquel de Lima Leite Soares Alvarenga; Samyra Maria dos Santos Nassif Lacerda

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)