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Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc by Lei Zhang; Wei Zhang; Jin Sun; Kui-nan Liu; Zhi-xue Gan; Yu-zhou Liu; Jian-feng Chang; Xiao-mei Yang; Feng Sun is a Neuroscience article available to read on EtoBox.

What is Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc about?

Gene mutations play important roles in tumour development. In this study, we identified a functional histone H2B mutation H2BL-T11C, causing an amino acid variation from Leu to Pro (L3P, H2BL-L3P). Cells overexpressing H2BL-L3P showed stronger proliferation, colony formation, tumourigenic abilities, and a different cell cycle distribution. Meanwhile, the c-Myc expression was elevated as evident by RNA-seq. We further revealed that an H2BK5ac-H2BK120ubi crosstalk which regulates gene transcription. Moreover, EdU staining demonstrated an important role of c-Myc in accelerating cell cycle progression through the G1/S checkpoint, while treatment with 10058-F4, an inhibitor of the c-Myc/MAX interaction, alleviated the abnormal cell proliferation and cell cycle distribution in vitro and partially inhibited tumour growth in vivo. The mutation of amino acid L3P is associated with tumour progression, suggesting patients carrying this SNP may have higher risk of tumour development.

Who reads Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc?

Author

Lei Zhang; Wei Zhang; Jin Sun; Kui-nan Liu; Zhi-xue Gan; Yu-zhou Liu; Jian-feng Chang; Xiao-mei Yang; Feng Sun

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)