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Fungal-derived Carboxymethyl Chitosan Blended with Polyvinyl Alcohol as Membranes for Wound Dressings by Kummara Madhusudana Rao; Kuncham Sudhakar; Maduru Suneetha; So Yeon Won; Sung Soo Han is a Materials Science article available to read on EtoBox.

What is Fungal-derived Carboxymethyl Chitosan Blended with Polyvinyl Alcohol as Membranes for Wound Dressings about?

Multifunctional blend membranes composed of poly (vinyl alcohol) (PVA) and fungal mushroom-derived carboxymethyl chitosan (F-CMCS) were produced using a simple solution casting technique for wound dressing applications. The structural interactions between PVA and F-CMCS were confirmed by Fourier infrared spectroscopy. The crystallinity of the membranes was examined by X-ray diffraction. Field emission scanning electron microscopy confirmed the homogeneity and coarser texture with a porous-like network in the internal structure of the membranes. The hydrophilicity, swelling, and degradation of the fabricated membranes were examined according to the F-CMCS content. The PVA/F-CMCS membrane displayed potential antibacterial activity against Escherichia coli (gram-negative) and Staphylococcus (gram-positive) bacteria. An in vitro cell study of skin fibroblasts and keratinocytes on the PVA/F-CMCS membranes confirmed the biocompatibility. The hemolysis assay demonstrated the hemocompatibility of the developed membranes. The antibacterial, biocompatibility, and good hemolysis in the PVA membrane were influenced by the F-CMCS composition ratio up to 40%. The allinclusive properties of the P

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Author

Kummara Madhusudana Rao; Kuncham Sudhakar; Maduru Suneetha; So Yeon Won; Sung Soo Han

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Materials Science (Physical Sciences)