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The document reviews the genotoxic and carcinogenic effects of nitrosamines, which are prevalent in various environmental sources and can lead to DNA alkylation damage. It discusses the metabolic activation of nitrosamines by CYP450 monooxygenases, resulting in DNA adducts, and outlines the DNA repair pathways, including base excision repair and nucleotide excision repair, that counteract this damage. The review emphasizes the importance of understanding these mechanisms to mitigate the risks associated wit

Author

zidoljoseph

Language

EN