Can I read Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial on EtoBox?

Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial by Sung-Jin Hong; Yong-Joon Lee; Seung-Jun Lee; Bum-Kee Hong; Woong Chol Kang; Jong-Young Lee; Jin-Bae Lee; Tae-Hyun Yang; Junghan Yoon; Chul-Min Ahn; Jung-Sun Kim; Byeong-Keuk Kim; Young-Guk Ko; Donghoon Choi; Yangsoo Jang; Myeong-Ki Hong; Myeong-Ki Hong; Donghoon Choi; Young-Guk Ko; Byeong-Keuk Kim; Jung-Sun Kim; Chul-Min Ahn; Sung-Jin Hong; Seung-Jun Lee; Yong-Joon Lee; Bum-Kee Hong; Hyuck Moon Kwon; Jong-Youn Kim; Pil Ki Min; Young Won Yoon; Byoung Kwon Lee; Se-Joong Rim; Eui-Young Choi; Woong Chol Kang; Pyung Chun Oh; Jong-Young Lee; Jin-Bae Lee; Kee Sik Kim; Ji Yong Choi; Jae Kean Ryu; Seung Pyo Hong; Chang Yeon Kim; Tae-Hyun Yang; Hyung-Jin Cho; Junghan Yoon; Min-Soo Ahn; Sung Gyun Ahn; Jun-Won Lee; Jung-Woo Son; Yangsoo Jang; Hyuck-Jun Yoon; Cheol Hyun Lee; Jongmin Hwang; Yun-Kyeong Cho; Seung-Ho Hur; Seongwook Han; Chang-Wook Nam; Hyoungseop Kim; Hyoung-Seob Park; In-Cheol Kim; Yun-Hyeong Cho; Hyeon-Ju Jeong; Jin-Ho Kim; Chewan Lim; Yongsung Suh; Eui Seok Hwang; Ji Hyun Lee; Sung Yun Lee; Sung Uk Kwon; Song-Yi Kim; Keun-Ho Park; Hyun Kuk Kim; LODESTAR Investigators is a Medicine article available to read on EtoBox.

What is Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial about?

## Importance In patients with coronary artery disease, some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is to begin with moderate-intensity statins and titrate to a specific LDL-C goal. These alternatives have not been compared head-to-head in a clinical trial involving patients with known coronary artery disease. ## Objective To assess whether a treat-to-target strategy is noninferior to a strategy of high-intensity statins for long-term clinical outcomes in patients with coronary artery disease. ## Design, Setting, and Participants A randomized, multicenter, noninferiority trial in patients with a coronary disease diagnosis treated at 12 centers in South Korea (enrollment: September 9, 2016, through November 27, 2019; final follow-up: October 26, 2022). ## Interventions Patients were randomly assigned to receive either the LDL-C target strategy, with an LDL-C level between 50 and 70 mg/dL as the target, or high-intensity statin treatment, which consisted of rosuvastatin, 20 mg, or atorvastatin, 40 mg. ## Main Outcomes and Measures Primary end

Who reads Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial?

Author

Sung-Jin Hong; Yong-Joon Lee; Seung-Jun Lee; Bum-Kee Hong; Woong Chol Kang; Jong-Young Lee; Jin-Bae Lee; Tae-Hyun Yang; Junghan Yoon; Chul-Min Ahn; Jung-Sun Kim; Byeong-Keuk Kim; Young-Guk Ko; Donghoon Choi; Yangsoo Jang; Myeong-Ki Hong; Myeong-Ki Hong; Donghoon Choi; Young-Guk Ko; Byeong-Keuk Kim; Jung-Sun Kim; Chul-Min Ahn; Sung-Jin Hong; Seung-Jun Lee; Yong-Joon Lee; Bum-Kee Hong; Hyuck Moon Kwon; Jong-Youn Kim; Pil Ki Min; Young Won Yoon; Byoung Kwon Lee; Se-Joong Rim; Eui-Young Choi; Woong Chol Kang; Pyung Chun Oh; Jong-Young Lee; Jin-Bae Lee; Kee Sik Kim; Ji Yong Choi; Jae Kean Ryu; Seung Pyo Hong; Chang Yeon Kim; Tae-Hyun Yang; Hyung-Jin Cho; Junghan Yoon; Min-Soo Ahn; Sung Gyun Ahn; Jun-Won Lee; Jung-Woo Son; Yangsoo Jang; Hyuck-Jun Yoon; Cheol Hyun Lee; Jongmin Hwang; Yun-Kyeong Cho; Seung-Ho Hur; Seongwook Han; Chang-Wook Nam; Hyoungseop Kim; Hyoung-Seob Park; In-Cheol Kim; Yun-Hyeong Cho; Hyeon-Ju Jeong; Jin-Ho Kim; Chewan Lim; Yongsung Suh; Eui Seok Hwang; Ji Hyun Lee; Sung Yun Lee; Sung Uk Kwon; Song-Yi Kim; Keun-Ho Park; Hyun Kuk Kim; LODESTAR Investigators

Publisher

American Medical Association (AMA)

Published

2023

Language

EN

Field

Medicine (Health Sciences)