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What is SABRE: Advanced Ligand-Based Screening about?

The document presents SABRE, a ligand/structure-based virtual screening approach that combines shape-based similarity with receptor binding site analysis to enhance drug candidate identification. The method utilizes a consensus molecular-shape pattern recognition to filter candidate structures, demonstrating superior performance in early retrieval rates of active compounds compared to traditional virtual screening methods. Validation against the Database of Useful Decoys shows SABRE

Author

yuchen.zhou.alien

Language

EN