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Time-dependent discrepancies between physician-assessed and patient-reported oxaliplatin-induced peripheral neuropathy in patients with metastatic colorectal cancer who received mFOLFOX6 plus bevacizumab: a post hoc analysis (WJOG4407GSS2) by Miura, Yuji; Ando, Masahiko; Yamazaki, Kentaro; Hironaka, Shuichi; Boku, Narikazu; Muro, Kei; Hyodo, Ichinosuke is a Medicine article available to read on EtoBox.

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## Purpose: Cumulative sensory neurotoxicity induced by oxaliplatin impairs patients' quality of life and treatment continuation. this study investigated the relationship between physician-assessed and patient-reported oxaliplatin-induced peripheral neuropathy (oipn) during treatment of metastatic colorectal cancer (mcrc) over time. ## Methods: A post hoc analysis was conducted for 191 patients with mcrc who received mfolfox6 plus bevacizumab in the wjog4407g trial. physician-assessed oipn was graded by ctcae every 2 weeks. patient-reported oipn was assessed with the fact/gog-ntx (11 items, best score 44) at baseline and at 3, 6, and 9 months. physician underestimation was defined as when the highest scores of the ntx1-4 sensory subscale/ctcae grade were 2/0, 3/0-1, or 4/0-1, and overestimation as 0/2-3, 1/2-3, or 2/3. ## Results: The median total dose (range) of oxaliplatin was 762 (85-5950) mg/m. overall, the least squares mean of fact/gog-ntx scores (standard error), estimated by a linear mixed model, were 36 (0.8), 34 (0.9), 29 (1.0), and 27 (1.1) for ctcae grades 0, 1, 2, and 3, respectively. fact/gog-ntx scores were weakly-to-moderately correlated with ctcae grade (spearman's

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Author

Miura, Yuji; Ando, Masahiko; Yamazaki, Kentaro; Hironaka, Shuichi; Boku, Narikazu; Muro, Kei; Hyodo, Ichinosuke

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0941-4355)

Published

2020

Language

EN

Field

Medicine (Health Sciences)