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Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer Using a Combination of Contrast‐enhanced Ultrasound and Dynamic Contrast‐enhanced Magnetic Resonance Imaging by Xue Han; Huajing Yang; Shiyang Jin; Yunfeng Sun; Hongxia Zhang; Ming Shan; Wen Cheng is a Medicine article available to read on EtoBox.

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## Abstract This study aimed to evaluate the value of dynamic contrast‐enhanced ultrasound (CEUS) combined with dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in predicting pathological complete response (pCR) in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). Fifty‐seven female patients with breast cancer (mean age, 50.46 years; range, 32–66 years) scheduled for NAC were recruited. CEUS and DCE‐MRI were performed before and after NAC. Imaging features and their changes were compared with postoperative pathological results. After the clinical differences were balanced using propensity score matching, univariate and multiple logistic regression analyses were used to derive the characteristics independently associated with pCR. Receiver operating characteristic curve analysis was performed to assess diagnostic performance. After six to eight cycles of NAC, 24 (42.1%) patients achieved pCR, while 33 (57.9%) did not. Multivariate analysis showed that enhancement order on CEUS and DCE‐MRI before NAC, reduction in diameter and enhancement shape on CEUS, maximum diameter on DCE‐MRI, and the type of progressive dynamic contrast enhancement after NAC we

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Author

Xue Han; Huajing Yang; Shiyang Jin; Yunfeng Sun; Hongxia Zhang; Ming Shan; Wen Cheng

Publisher

Wiley

Published

2022

Language

EN

Field

Medicine (Health Sciences)