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Can I read Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers on EtoBox?
Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers by Martina Reiter; Vanessa M. Walf; Arne Christians; Michael W. Pfaffl; Heinrich H.D. Meyer is a Chemistry article available to read on EtoBox.
What is Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers about?
With this feasibility study a first step towards a new monitoring system for hormonal treatments was done. Screening of regulation and function of anabolic sex steroids via modified gene expression of mRNA in various tissues could be a new approach to trace treatments with unknown drugs or newly combined cocktails. In the study, uterus, liver and muscle tissue from 24 cycling heifers were taken after the animals were treated either with Melengestrol Acetate (MGA), Finaplix-H ® (200 mg Trenbolone Acetate) or Ralgro ® (36 mg Zeranol) for 56 days. In every treatment group always two heifers were given 1-fold, 3-fold and 10-fold doses of the standard preparation, the control group without any treatment consisted of two animals. The different tissue gene expression profiles were investigated via the candidate gene approach. Totally 57 candidate genes were selected according to their functionality by screening the actual literature and composed to functional groups: angiogenesis, apoptosis, cell cycle, endocrine factors, energy metabolism, inflammatory factors, muscle function, oncogenes, protein metabolism and transcription factors. Gene expression was measured using quantitative real-t
Who reads Modification of mRNA expression after treatment with anabolic agents and the usefulness for gene expression-biomarkers?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Martina Reiter; Vanessa M. Walf; Arne Christians; Michael W. Pfaffl; Heinrich H.D. Meyer
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0003-2670)
- Published
- 2007
- Language
- EN
- Field
- Chemistry (Physical Sciences)