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Can I read Determinants to Optimize Response to Clopidogrel in Acute Coronary Syndrome on EtoBox?
Determinants to Optimize Response to Clopidogrel in Acute Coronary Syndrome by Giusti, Betti is a Medicine article available to read on EtoBox.
What is Determinants to Optimize Response to Clopidogrel in Acute Coronary Syndrome about?
The inhibition of platelet function by antiplatelet therapy determines the improvement of the survival of patients with clinically evident cardiovascular disease. Clopidogrel in combination with aspirin is the recommended standard of care for reducing the occurrence of cardiovascular events in patients with acute coronary syndromes undergoing percutaneous coronary intervention. However, major adverse cardiovascular events including stent thrombosis occur in patients taking clopidogrel and aspirin. A growing body of evidence demonstrates that high post-treatment platelet reactivity on antiplatelet treatment is associated with increased risk of adverse clinical events. Clopidogrel requires conversion to active metabolite by cytochrome P450 isoenzymes. The active metabolite inhibits ADP-stimulated platelet activation by irreversibly binding to P2Y(12) receptors. Recently, the loss-of-function CYP2C19\*2 allele has been associated with decreased metabolization of clopidogrel, poor antiaggregant effect, and increased cardiovascular events. In high risk vascular patients, the CYP2C19\*2 polymorphism is a strong predictor of adverse cardiovascular events and particularly of stent thrombos
Who reads Determinants to Optimize Response to Clopidogrel in Acute Coronary Syndrome?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Giusti, Betti
- Publisher
- Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; [Auckland N.Z.]: Dove Medical Press, c2008-; Informa UK Limited (ISSN 1178-7066)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Life Sciences)