Opening book details…
Can I read In Vitro and in Vivo Degradation Correlations for Polyurethane Foams with Tunable Degradation Rates on EtoBox?
In Vitro and in Vivo Degradation Correlations for Polyurethane Foams with Tunable Degradation Rates by Anand Utpal Vakil; Natalie Marie Petryk; Changling Du; Bryanna Howes; Darnelle Stinfort; Serenella Serinelli; Lorenzo Gitto; Maryam Ramezani; Henry T. Beaman; Mary Beth Browning Monroe is a Engineering article available to read on EtoBox.
What is In Vitro and in Vivo Degradation Correlations for Polyurethane Foams with Tunable Degradation Rates about?
Polyurethane foams present a tunable biomaterial platform with potential for use in a range of regenerative medicine applications. Achieving a balance between scaffold degradation rates and tissue ingrowth is vital for successful wound healing, and significant in vivo testing is required to understand these processes. Vigorous in vitro testing can minimize the number of animals that are required to gather reliable data; however, it is difficult to accurately select in vitro degradation conditions that can effectively mimic in vivo results. To that end, we performed a comprehensive in vitro assessment of the degradation of porous shape memory polyurethane foams with tunable degradation rates using varying concentrations of hydrogen peroxide to identify the medium that closely mimics measured in vivo degradation rates. Material degradation was studied over 12 weeks in vitro in 1%, 2%, or 3% hydrogen peroxide and in vivo in subcutaneous pockets in Sprague Dawley rats. We found that the in vitro degradation conditions that best predicted in vivo degradation rates varied based on the number of mechanisms by which the polymer degraded and the polymer hydrophilicity. Namely, more hydrophi
Who reads In Vitro and in Vivo Degradation Correlations for Polyurethane Foams with Tunable Degradation Rates?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Anand Utpal Vakil; Natalie Marie Petryk; Changling Du; Bryanna Howes; Darnelle Stinfort; Serenella Serinelli; Lorenzo Gitto; Maryam Ramezani; Henry T. Beaman; Mary Beth Browning Monroe
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)