Opening book details…
Can I read Structure‐activity studies of N,N‐dialkyl and cycloalkyl carbamate esters of dimethylethanolamine and choline with nicotinic and muscarinic cholinergic properties on EtoBox?
Structure‐activity studies of N,N‐dialkyl and cycloalkyl carbamate esters of dimethylethanolamine and choline with nicotinic and muscarinic cholinergic properties by Manda Saraswati; Nicole Lerner‐Marmarosh; David X. Wang; Shey‐Shing Sheu; Viranda Sharma; Leo G. Abood is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structure‐activity studies of N,N‐dialkyl and cycloalkyl carbamate esters of dimethylethanolamine and choline with nicotinic and muscarinic cholinergic properties about?
## Abstract Structure‐activity studies were performed on a series of newly synthesized N‐sub‐stituted carbamate esters of choline and dimethylethanolamine which exhibited either or both nicotinic and muscarinic cholinergic properties. Substitutions on the carbamyl N consisted of varying lengths of dialkyls, diphenyl, and various heterocycles. The compounds were evaluated for their nicotinic and muscarinic receptor binding properties in rat brain membranes, their effect on muscarinic receptor‐activated phosphoinositide (PI) turnover in rat cortical slices, and for muscarinic receptor‐mediated intracelluar Ca release in a mouse adrenal carcinoma cell line transfected with an m1 muscarinic cholinergic receptor gene. N,N‐diethylcarbamylcholine had the highest affinity for nicotinic cholinergic receptors; the K~i~ value of 1 × 10^−9^ M approached that of nicotine and being 1/5 that for the dimethyl analogue. With increasing chain length of the dialkyl substituents the nicotinic affinity progressively decreased, while muscarinic affinity increased. N,N‐diphenylcarbamylcholine had a K~i~ value of 1 × 10^−7^ M for nicotinic receptors and exhibited nicotinic antagonist activity. Contrary to
Who reads Structure‐activity studies of N,N‐dialkyl and cycloalkyl carbamate esters of dimethylethanolamine and choline with nicotinic and muscarinic cholinergic properties?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Manda Saraswati; Nicole Lerner‐Marmarosh; David X. Wang; Shey‐Shing Sheu; Viranda Sharma; Leo G. Abood
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0272-4391)
- Published
- 1994
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)