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Innovative transdermal drug delivery system based on amoxicillin-loaded gelatin methacryloyl microneedles obtained by 3D printing by Huseyin Erkus; Tuba Bedir; Elif Kaya; Gulgun Bosgelmez Tinaz; Oguzhan Gunduz; Mariana-Carmen Chifiriuc; Cem Bulent Ustundag is a Engineering article available to read on EtoBox.
What is Innovative transdermal drug delivery system based on amoxicillin-loaded gelatin methacryloyl microneedles obtained by 3D printing about?
The microneedle (MN) technology platform has a significant potential for enhancing the efficacy of transdermal drug delivery, by using micron-scale arrays with restricted geometries that pierce the skin non-invasively. In this paper, we developed gelatin methacryloyl (GelMA) MNs containing amoxicillin (AMX) as a novel transdermal delivery system using digital light processing (DLP) based 3D printing technology. With the DLP approach, MNs were obtained with high resolution and minimal lead times without geometric limitations. The 3D-printed AMX-loaded GelMA MNs were examined for their morphological, mechanical, swelling and antimicrobial properties as well as the drug release profile. The morphological analysis demonstrated the successful fabrication of the MNs with regular structure and sharp tips. The fabricated MNs displayed good mechanical properties consistent with 0.1 N/needle without breaking. Moreover, the results of the in vitro antibacterial activity assays indicated that AMX-loaded GelMA MNs have significantly inhibited the Staphylococcus aureus and Escherichia coli growth. These findings suggest that the 3D-printed drug-loaded GelMA MNs are a useful platform for transder
Who reads Innovative transdermal drug delivery system based on amoxicillin-loaded gelatin methacryloyl microneedles obtained by 3D printing?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Huseyin Erkus; Tuba Bedir; Elif Kaya; Gulgun Bosgelmez Tinaz; Oguzhan Gunduz; Mariana-Carmen Chifiriuc; Cem Bulent Ustundag
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)