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Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis by Rosato, A. Scotto; Tang, R.; Grimm, C. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis about?

The old Greek saying "Panta Rhei" ("everything flows") is true for all life and all living things in general. It also becomes nicely evident when looking closely into cells. There, material from the extracellular space is taken up by endocytic processes and transported to endosomes where it is sorted either for recycling or degradation. Cargo is also packaged for export through exocytosis involving the Golgi network, lysosomes and other organelles. Everything in this system is in constant motion and many proteins are necessary to coordinate transport along the different intracellular pathways to avoid chaos. Among these proteins are ion channels., in particular TRPML channels (mucolipins) and two-pore channels (TPCs) which reside on endosomal and lysosomal membranes to speed up movement between organelles, e.g. by regulating fusion and fission; they help readjust pH and osmolarity changes due to such processes, or they promote exocytosis of export material. Pathophysiologically, these channels are involved in neurodegenerative, metabolic, retinal and infectious diseases, cancer, pigmentation defects, and immune cell function, and thus have been proposed as novel pharmacological tar

Who reads Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis?

Author

Rosato, A. Scotto; Tang, R.; Grimm, C.

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0163-7258)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)