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The Deubiquitylase OTUB1 Mediates Ferroptosis Via Stabilization of SLC7A11 by 3171912636 is a document available to read on EtoBox.

This study identifies the deubiquitylase OTUB1 as a crucial regulator of SLC7A11, a key component in the ferroptosis process, which is a nonapoptotic form of cell death that suppresses tumor development. OTUB1 stabilizes SLC7A11 and its inactivation leads to reduced tumor growth and increased sensitivity to ferroptosis in cancer cells. The findings suggest that targeting OTUB1 could be a potential strategy for cancer therapy by modulating ferroptotic responses.

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3171912636

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EN