Can I read Efficacy of Adjunctive Intensive Transcranial Direct Current Stimulation of Different Cortices in Treatment-resistant Depression: a Study Protocol for a Randomized Double-blinded Sham-controlled Trial on EtoBox?

Efficacy of Adjunctive Intensive Transcranial Direct Current Stimulation of Different Cortices in Treatment-resistant Depression: a Study Protocol for a Randomized Double-blinded Sham-controlled Trial by Yiming Chen; Dongbin Lyu; Fan Wang; Qinte Huang; Weichieh Yang; Mengke Zhang; Zheyi Wei; Shuxiang Shi; Shuqi Kong; Shentse Chen; Shuang He; Vivien Yang; Yiru Fang; Wu Hong is a Psychology article available to read on EtoBox.

What is Efficacy of Adjunctive Intensive Transcranial Direct Current Stimulation of Different Cortices in Treatment-resistant Depression: a Study Protocol for a Randomized Double-blinded Sham-controlled Trial about?

## Abstract ## Background Treatment-resistant depression (TRD) carries a high economic burden worldwide. Transcranial direct current stimulation (tDCS) is advantageous for improving cognition and can be safely used in the treatment of depression. The effectiveness of tDCS of the left and right orbitofrontal cortex (OFC) as adjuvant treatment in patients with TRD has rarely been explored. Therefore, the objective of this trial is to evaluate the effectiveness there of when administering left dorsolateral prefrontal cortex (DLPFC) positive stimulation or OFC negative stimulation in patients with TRD. ## Methods Ninety eligible participants will be recruited to receive intervention at Shanghai Mental Health Center. Treatment will be randomly assigned in a double-blind fashion. Participants will receive either DLPFC (n = 30), OFC (n = 30), or sham (n = 30) tDCS, while continuing their usual pharmacotherapy at a stable dosage for at least 2 weeks before enrollment and throughout the stimulation period. All participants will receive 20 weekday stimulation sessions of 60 minutes duration each. Participants in the active group will be stimulated at 2 mA throughout the session, whereas the

Who reads Efficacy of Adjunctive Intensive Transcranial Direct Current Stimulation of Different Cortices in Treatment-resistant Depression: a Study Protocol for a Randomized Double-blinded Sham-controlled Trial?

Author

Yiming Chen; Dongbin Lyu; Fan Wang; Qinte Huang; Weichieh Yang; Mengke Zhang; Zheyi Wei; Shuxiang Shi; Shuqi Kong; Shentse Chen; Shuang He; Vivien Yang; Yiru Fang; Wu Hong

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Psychology (Social Sciences)