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What is Targeting FA Pathway to Enhance Chemotherapy about?

Chemotherapy remains one of the most effective cancer treatments, but drug resistance limits its effectiveness. Targeting DNA repair pathways can sensitize cells to chemotherapy. This study explores targeting the Fanconi anemia (FA) pathway using an adenovirus expressing a dominant-negative FANCA mutant to disrupt the pathway. This sensitized tumor cell lines, including non-small cell lung cancer cells, approximately 2-3-fold to cisplatin, demonstrating targeting DNA repair pathways through gene therapy is

Author

Vaishnavi Balaji

Language

EN