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Can I read Nanotechnology-Based Cisplatin Intracellular Delivery to Enhance Chemo-Sensitivity of Ovarian Cancer on EtoBox?
Nanotechnology-Based Cisplatin Intracellular Delivery to Enhance Chemo-Sensitivity of Ovarian Cancer by Barbara Bortot; Maurizio Mongiat; Erica Valencic; Simeone Dal Monego; Danilo Licastro; Matteo Crosera; Gianpiero Adami; Enrico Rampazzo; Giuseppe Ricci; Federico Romano; Giovanni Maria Severini; Stefania Biffi is a Materials Science article available to read on EtoBox.
What is Nanotechnology-Based Cisplatin Intracellular Delivery to Enhance Chemo-Sensitivity of Ovarian Cancer about?
## Background Platinum resistance is a major challenge in the management of ovarian cancer. Even low levels of acquired resistance at the cellular level lead to impaired response to cisplatin. In ovarian cancer intraperitoneal therapy, nanoparticle formulation can improve the cisplatin’s pharmacokinetics and safety profile. ## Purpose This work aimed to investigate the chemo-sensitivity of ovarian cancer SKOV3 cells upon short-term (72h) single treatment of cisplatin and cisplatin-loaded biodegradable nanoparticles (Cis-NP). The aim was then to determine the therapeutic properties of Cis-NP in vivo using a SKOV3-luc cells’ xenograft model in mice. ## Methods Cell cytotoxicity was assessed after the exposure of the cell culture to cisplatin or Cis-NP. The effect of treatments on EMT and CSC-like phenotype was studied by analyzing a panel of markers by flow cytometry. Intracellular platinum concentration was determined by inductively coupled plasma mass spectrometry (ICS-MS), and gene expression was evaluated by RNAseq analysis. The efficacy of intraperitoneal chemotherapy was evaluated in a SKOV3-luc cells’ xenograft model in mice, through a combination of bioluminescence imaging, h
Who reads Nanotechnology-Based Cisplatin Intracellular Delivery to Enhance Chemo-Sensitivity of Ovarian Cancer?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Barbara Bortot; Maurizio Mongiat; Erica Valencic; Simeone Dal Monego; Danilo Licastro; Matteo Crosera; Gianpiero Adami; Enrico Rampazzo; Giuseppe Ricci; Federico Romano; Giovanni Maria Severini; Stefania Biffi
- Publisher
- Informa UK Limited
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)