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Lactose Permease Sugar Uptake Dynamics by Thales Freire is a document available to read on EtoBox.
This study investigates the sugar uptake dynamics of the Lactose permease (LacY) transporter in Escherichia coli using extended simulations and metadynamics sampling. The research identifies a putative sugar-uptake pathway involving specific residues and lipid interactions, revealing the flexibility of the protein at the periplasmic side and detailing the binding free energy landscape. The findings enhance the understanding of substrate affinity and specificity in LacY, providing insights into the molecular
- Author
- Thales Freire
- Language
- EN