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Increased local concentrations of growth factors from leucocyte‐ and platelet‐rich fibrin do not translate into improved alveolar ridge preservation: An intra‐individual mechanistic randomized controlled trial by Xuzhu Wang; Melissa R. Fok; George Pelekos; Lijian Jin; Maurizio S. Tonetti is a Dentistry article available to read on EtoBox.

What is Increased local concentrations of growth factors from leucocyte‐ and platelet‐rich fibrin do not translate into improved alveolar ridge preservation: An intra‐individual mechanistic randomized controlled trial about?

## Abstract ## Aim Leucocyte‐ and platelet‐rich fibrin (L‐PRF) has been tested for enhancing alveolar ridge preservation (ARP), but little is known about the local release profile of growth factors (GF), and the clinical equipoise related to its efficacy remains. This study compared the patterns of GF release, early soft tissue healing, and alveolar ridge resorption following unassisted healing and L‐PRF application in non‐molar extraction sockets. ## Materials and Methods Atraumatic tooth extraction of two hopeless teeth per patient was followed by unassisted healing or L‐PRF placement to fill the socket in 18 systemically healthy, non‐smoking subjects. This intra‐individual trial was powered to assess changes in horizontal alveolar ridge dimensions 1 mm below the crest of alveolar bone. GF concentrations in wound fluid were assessed with a multiplex assay at 6, 24, 72, and 168 h. Early healing was evaluated with the wound healing index and changes in soft tissue volumes on serial digital scans. Hard tissue changes were measured on superimposed CBCT images after 5 months of healing. ## Results L‐PRF resulted in higher GF concentrations in wound fluid (WF) than in the control, but

Who reads Increased local concentrations of growth factors from leucocyte‐ and platelet‐rich fibrin do not translate into improved alveolar ridge preservation: An intra‐individual mechanistic randomized controlled trial?

Author

Xuzhu Wang; Melissa R. Fok; George Pelekos; Lijian Jin; Maurizio S. Tonetti

Publisher

Wiley

Published

2022

Language

EN

Field

Dentistry (Health Sciences)