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Time course of GLUT4 and AMPK protein expression in human skeletal muscle during one month of physical training by J. Langfort; M. Viese; T. Ploug; F. Dela is a Medicine article available to read on EtoBox.

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Endurance training elicits profound adaptations of skeletal muscle, including increased expression of several proteins. The 5′‐AMP activated protein kinase (AMPK) may be one of these, considering the fact that acute exercise increases AMPK activity. Eight young (26 ± 1 year) lean, healthy males endurance trained one leg (while the other leg remained resting) on an ergometer bicycle for 30 min/day for four weeks (workload corresponding to ∼70% of maximal oxygen uptake). Muscle biopsies were obtained ∼18 h after the previous training session. On day eight GLUT4 protein expression was 36% higher in trained (T) compared with untrained (UT) (__P__ < 0.05), but no further increase was seen at day 14 and 30 despite continuously increasing absolute workloads. Expression of AMPKα~2~ and actin did not change with training. In contrast, expression of AMPKα~1~ was 27% higher in T vs. UT muscle (__P__ < 0.05) (measured only on day 30). Conclusions: GLUT4 protein expression increases substantially after seven days of endurance training with no further increase with prolonged training at progressively increasing workloads. AMPKα~1~ and α~2~ behave differently in their expression in response to en

Who reads Time course of GLUT4 and AMPK protein expression in human skeletal muscle during one month of physical training?

Author

J. Langfort; M. Viese; T. Ploug; F. Dela

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0905-7188)

Published

2003

Language

EN

Field

Medicine (Health Sciences)