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Modeling the Onset of Virulence in a Pectinolytic Bacterium by Jacques-A. Sepulchre; Sylvie Reverchon; William Nasser is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Modeling the Onset of Virulence in a Pectinolytic Bacterium about?

Building up from experimental knowledge of the regulatory network of the pel genes in the bacteria E. chrysanthemi, we propose for the first time a qualitative modeling of the infectious transition of this bacteria when it is hosted in a plant. We show that this infectious transition can be understood as the excitable dynamics of a metabolico-genetic network. Our mathematical model can account for the main phases which are observed in the onset of the pathogenecity by Erwinia chrysanthemi, namely the silent, latent and virulent stages. Like in many infectious agents, the silent state corresponds to the growth phase of the bacteria, where they multiply without significantly producing molecules which could trigger a counter attack of the invaded host. The latent stage is characterized by a moderate but unequivocal expression of the virulence gene, waiting for a number of conditions which have to fulfill in order to trigger a fully developed infection. In the virulent state the bacteria synthesize a massive production of virulence factors including pectate lyases (Pel) which favor the invasion of the host plant tissues. Our model is able to show cases of transitions from the silent to

Who reads Modeling the Onset of Virulence in a Pectinolytic Bacterium?

Author

Jacques-A. Sepulchre; Sylvie Reverchon; William Nasser

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)