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Initial experience of using intensity modulated radiation therapy (IMRT) for recurrent nasopharyngeal carcinoma by L.Tai Xiang; C Zhao; F Han; Y Huang; X Deng; S Huang; Z Zeng; C Lin; N Cui is a Medicine article available to read on EtoBox.

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chemotherapy. Radiosurgery was delivered to the primary tumor site 4 weeks after the completion of EBRT in one fraction of 7-15 Gy (median 12 Gy). Results: With a median follow up of 31.4 months (range: 3.9-84.6), there were 14 distant relapses, but no local failures. The 3-year local control rate was 100%, freedom from distant metastasis (FFDM) was 69% and overall survival was 75%. Univariate analysis revealed that N-stage (favoring N0-1, p ϭ 0.04) and WHO histology (favoring WHO III, p ϭ 0.0001) were significant prognostic factors for FFDM. WHO histology was the only significant factor for FFDM on multivariate analysis (pϭ 0.002, hazard ratio (HR) ϭ 13). Age (p ϭ 0.04), gender (favoring female, p ϭ 0.04) and WHO histology were significant prognostic factors for survival on univariate analysis. WHO histology (pϭ0.004, HR ϭ 10.5) and age (pϭ0.01, HR 1.07/year) were significant factors for survival on multivariate analysis. Late toxicity included transient cranial nerve weakness in 4, radiation-related retinopathy in 1 and asymptomatic temporal lobe necrosis in 3 patients who originally had intracranial tumor extension. Conclusions: Stereotactic radiosurgical boost following fractio

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Author

L.Tai Xiang; C Zhao; F Han; Y Huang; X Deng; S Huang; Z Zeng; C Lin; N Cui

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2002

Language

EN

Field

Medicine (Health Sciences)