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Comparison of Low-molecular-weight Heparin and Antithrombin Versus Antithrombin Alone for the Prevention of Symptomatic Venous Thromboembolism in Children with Acute Lymphoblastic Leukemia by Bernhard Meister; Gabriele Kropshofer; Andreas Klein-Franke; Alexander M. Strasak; Josef Hager; Werner Streif is a Medicine article available to read on EtoBox.
What is Comparison of Low-molecular-weight Heparin and Antithrombin Versus Antithrombin Alone for the Prevention of Symptomatic Venous Thromboembolism in Children with Acute Lymphoblastic Leukemia about?
## Abstract ## Background Children with acute lymphoblastic leukemia (ALL) have a substantial risk for thromboembolism (TE) that is related to __L__‐asparaginase‐induced antithrombin (AT) deficiency and placement of central venous lines. Recent __in vitro__ studies showed that the anticoagulant effects of low‐molecular‐weight heparin were profoundly affected by endogenous AT levels in children undergoing ALL therapy. ## Methods A total of 112 consecutively recruited children with newly diagnosed ALL treated according to BFM 95/2000 protocols were enrolled in this trial. This prospective cohort study was carried out to determine the influence of combined low molecular weight heparin‐prophylaxis (enoxaparin 1 mg/kg/ per day) and AT supplementation versus AT alone (noncontemporaneous control group) on the incidence of symptomatic TE during a follow‐up of 240 days. ## Results To maintain AT plasma levels above 50%, nearly 60% of all children needed at least one, most children two or three AT supplementations during induction therapy. 12.7% of the children that did receive only AT‐prophylaxis (n = 71) (95% CI = 6.0–22.7) developed objectively confirmed symptomatic TE, as compared with n
Who reads Comparison of Low-molecular-weight Heparin and Antithrombin Versus Antithrombin Alone for the Prevention of Symptomatic Venous Thromboembolism in Children with Acute Lymphoblastic Leukemia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Bernhard Meister; Gabriele Kropshofer; Andreas Klein-Franke; Alexander M. Strasak; Josef Hager; Werner Streif
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)