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The study investigates the antitumor effects of harmaline (HAR), a β-carboline alkaloid from Peganum harmala, on gastric cancer cells (SGC-7901). HAR induces G2/M cell cycle arrest and apoptosis by up-regulating Fas/FasL signaling and altering the expression of cell cycle-related proteins. In vivo experiments demonstrate that HAR effectively inhibits tumor growth without significant systemic toxicity at moderate doses.

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h576218540

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EN