Can I read Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy on EtoBox?
Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy by Benjamin E. Zusman; Patrick M. Kochanek; Ruchira M. Jha is a Medicine article available to read on EtoBox.
What is Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy about?
Purpose of review The purposes of this narrative review are to (1) summarize a contemporary view of cerebral edema pathophysiology, (2) present a synopsis of current management strategies in the context of their historical roots (many of which date back multiple centuries), and (3) discuss contributions of key molecular pathways to overlapping edema endophenotypes. This may facilitate identification of important therapeutic targets. Recent findings Cerebral edema and resultant intracranial hypertension are major contributors to morbidity and mortality following traumatic brain injury. Although Starling forces are physical drivers of edema based on differences in intravascular vs extracellular hydrostatic and oncotic pressures, the molecular pathophysiology underlying cerebral edema is complex and remains incompletely understood. Current management protocols are guided by intracranial pressure measurements, an imperfect proxy for cerebral edema. These include decompressive craniectomy, external ventricular drainage, hyperosmolar therapy, hypothermia, and sedation. Results of contemporary clinical trials assessing these treatments are summarized, with an emphasis on the gap between i
Who reads Cerebral Edema in Traumatic Brain Injury: a Historical Framework for Current Therapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Benjamin E. Zusman; Patrick M. Kochanek; Ruchira M. Jha
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)