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The role of donor T cells for target organ injuries in acute and chronic graft‐versus‐host disease by Yasuro Kataoka; Tsuyoshi Iwasaki; Takanori Kuroiwa; Yoshifumi Seto; Nobuo Iwata; Naoaki Hashimoto; Atsushi Ogata; Teruaki Hamano; Eizo Kakishita is a Immunology and Microbiology article available to read on EtoBox.

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## Summary Donor T cells are crucial for target organ injury in graft‐versus‐host disease (GVHD). We examined the effects of donor T cells on the target organs using a parent‐into‐F~1~ model of acute and chronic GVHD. Donor T cells showed engraftment in the spleen, small intestine and liver of mice with acute GVHD, causing typical GVHD pathology in these organs. Interferon‐γ and Fas ligand expression were up‐regulated, and host lymphocytes were depleted in the target organs of these mice. In contrast, donor T cells did not show engraftment in the small intestine of mice with chronic GVHD, and no GVHD pathology was observed in this organ. However, both donor T‐cell engraftment and GVHD pathology were observed in the spleen and liver of chronic GVHD mice, along with the up‐regulation of interleukin‐4 (IL‐4) and IL‐10 expression plus the expansion of host lymphocytes such as splenic B cells and hepatic natural killer (NK) 1.1^+^ T cells. Donor anti‐host cytotoxic T‐lymphocyte activity was observed in spleen cells from mice with acute GVHD, but not in spleen cells from mice with chronic GVHD. Transplantation of Fas ligand‐deficient (__gld__) spleen cells did not induce host lymphocyte

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Author

Yasuro Kataoka; Tsuyoshi Iwasaki; Takanori Kuroiwa; Yoshifumi Seto; Nobuo Iwata; Naoaki Hashimoto; Atsushi Ogata; Teruaki Hamano; Eizo Kakishita

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

2001

Language

EN

Field

Immunology and Microbiology (Life Sciences)