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Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis by Shihao Xie; Jiaxin Li; Fengyuan Lyu; Qingming Xiong; Peng Gu; Yuqi Chen; Meiling Chen; Jingna Bao; Xianglong Zhang; Rongjuan Wei; Youpeng Deng; Hongzheng Wang; Zhenhua Zeng; Zhongqing Chen; Yongqiang Deng; Zhuoshi Lian; Jie Zhao; Wei Gong; Ye Chen; Ke-Xuan Liu; Yi Duan; Yong Jiang; Hong-Wei Zhou; Peng Chen is a Medicine article available to read on EtoBox.

What is Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis about?

## Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic proinflammatory phase is one of the key drivers of organ failure and consequent mortality.Akkermansia muciniphila(AKK) is recognised as a functional probiotic strain that exerts beneficial effects on the progression of many diseases; however, whether AKK participates in sepsis pathogenesis is still unclear. Here, we evaluated the potential contribution of AKK to lethal sepsis development. ## Design Relative abundance of gut microbial AKK in septic patients was evaluated. Cecal ligation and puncture (CLP) surgery and lipopolysaccharide (LPS) injection were employed to establish sepsis in mice. Non-targeted and targeted metabolomics analysis were used for metabolites analysis. ## Results We first found that the relative abundance of gut microbial AKK in septic patients was significantly reduced compared with that in non-septic controls. Live AKK supplementation, as well as supplementation with its culture supernatant, remarkably reduced sepsis-induced mortality in sepsis models. Metabolomics analysis and germ-free mouse validation experiments revealed that live AKK was able to generate a novel tripept

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Author

Shihao Xie; Jiaxin Li; Fengyuan Lyu; Qingming Xiong; Peng Gu; Yuqi Chen; Meiling Chen; Jingna Bao; Xianglong Zhang; Rongjuan Wei; Youpeng Deng; Hongzheng Wang; Zhenhua Zeng; Zhongqing Chen; Yongqiang Deng; Zhuoshi Lian; Jie Zhao; Wei Gong; Ye Chen; Ke-Xuan Liu; Yi Duan; Yong Jiang; Hong-Wei Zhou; Peng Chen

Publisher

BMJ

Published

2023

Field

Medicine (Health Sciences)