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Growth Hormone As A Cytokine by MJ Waters; CA Shang; SN Behncken; S‐P Tam; H Li; B Shen; PE Lobie is a Medicine article available to read on EtoBox.

What is Growth Hormone As A Cytokine about?

## SUMMARY 1. The growth hormone (GH) receptor was the first of the class 1 cytokine receptors to be cloned. It shares a number of structural characteristics with other family members and common signalling mechanisms based on common usage of the Janus kinase 2 (JAK2). 2. Growth hormone receptor activation is initiated by GH‐induced homodimerization of receptor molecules. This has enabled the creation of specific hormone antagonists that block receptor dimerization. 3. The details of the transcription factors used by the activated receptor are being revealed as a result of promoter analyses and electrophoretic mobility gelshift analysis. 4. Growth hormone receptors are widespread and their discovery in certain tissues has led to the assignment of new physiological roles for GH. Some of these involve local or paracrine roles for GH, as befits its cytokine status. 5. Four examples of such novel roles are discussed. These are: (i) the brain GH axis; (ii) GH and the vitamin B~12~ axis; (iii) GH in early pre‐implantation development; and (iv) GH in development of the tooth. 6. We propose that the view that GH acts through the intermediacy of insulin‐like growth factor‐1 is simplistic; ra

Who reads Growth Hormone As A Cytokine?

Author

MJ Waters; CA Shang; SN Behncken; S‐P Tam; H Li; B Shen; PE Lobie

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

1999

Language

GA

Field

Medicine (Health Sciences)