Opening book details…
Can I read Alkyl vs. Aryl Modifications: a Comparative Study on Modular Modifications of Triphenylphosphonium Mitochondrial Vectors on EtoBox?
Alkyl vs. Aryl Modifications: a Comparative Study on Modular Modifications of Triphenylphosphonium Mitochondrial Vectors by Ong, How Chee (author);Coimbra, João T. S. (author);Kwek, Germain (author);Ramos, Maria J. (author);Xing, Bengang (author);Fernandes, Pedro A. (author);García, Felipe (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Alkyl vs. Aryl Modifications: a Comparative Study on Modular Modifications of Triphenylphosphonium Mitochondrial Vectors about?
Triphenylphosphonium (TPP^+^) moieties are commonly conjugated to drug molecules to confer mitochondrial selectivity due to their positive charge and high lipophilicity. Although optimisation of lipophilicity can be achieved by modifying the length of the alkyl linkers between the TPP^+^ moiety and the drug molecule, it is not always possible. While methylation of the TPP^+^ moiety is a viable alternative to increase lipophilicity and mitochondrial accumulation, there are no studies comparing these two separate modular approaches. Thus, we have systematically designed, synthesised and tested a range of TPP^+^ molecules with varying alkyl chain lengths and degree of aryl methylation to compare the two modular methodologies for modulating lipophilicity. The ability of aryl/alkyl modified TPP^+^ to deliver cargo to the mitochondria was also evaluated by confocal imaging with a TPP^+^-conjugated fluorescein-based fluorophore. Furthermore, we have employed molecular dynamics simulations to understand the translocation of these molecules through biological membrane model systems. These results provide further insights into the thermodynamics of this process and the effect of alkyl and ar
Who reads Alkyl vs. Aryl Modifications: a Comparative Study on Modular Modifications of Triphenylphosphonium Mitochondrial Vectors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ong, How Chee (author);Coimbra, João T. S. (author);Kwek, Germain (author);Ramos, Maria J. (author);Xing, Bengang (author);Fernandes, Pedro A. (author);García, Felipe (author)
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)