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PRRX1 promotes lymph node metastasis of gastric cancer by regulating epithelial-mesenchymal transition by Jibin Yao; Yongbin Zhang; Yu Xia; Chenglou Zhu; Xiaoxiong Wen; Tianxiang Liu; Mingxu Da is a scholarly article available to read on EtoBox.

What is PRRX1 promotes lymph node metastasis of gastric cancer by regulating epithelial-mesenchymal transition about?

## Abstract ## Background: Gastric cancer has multiple metastasis pathways, of which lymph node metastasis plays a dominant role. However, the specific mechanism of lymph node metastasis is still not unclear. ## Methods: The bioinformatics technology was utilized to mine gene chip data related to gastric cancer and Epithelial-Mesenchymal Transition (EMT) in a high-throughput gene expression database (Gene Expression Omnibus, GEO), we screened out all genes that have differential expression levels in gastric cancer tissues and in adjacent normal gastric mucosa tissues. The corresponding function package of R language software were performed for gene annotation and cluster analysis, then enrichment analysis of genes with differential expression and protein interaction network diagram for correlation analysis were performed, we finally screened out the paired related homeobox 1 gene (PRRX1) related to EMT. Next, we collected 65 metastatic lymph node samples and 93 gastric cancer tissue samples. The expression levels of PRRX1 and EMT-related protein E-cadherin (E-ca) and vimentin (Vim) in gastric cancer tissues and metastatic lymph node tissues were determined by immunohistochemistry (

Author

Jibin Yao; Yongbin Zhang; Yu Xia; Chenglou Zhu; Xiaoxiong Wen; Tianxiang Liu; Mingxu Da

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2021

Language

EN