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Targeting Cancer-associated Fibroblasts with Hydroxyethyl Starch Nanomedicine Boosts Cancer Therapy by Chong Wang; Huimin Wang; Hai Yang; Chen Xu; Qiang Wang; Zheng Li; Zhijie Zhang; Jiankun Guan; Ximiao Yu; Xiaoquan Yang; Xiangliang Yang; Zifu Li is a Materials Science article available to read on EtoBox.

What is Targeting Cancer-associated Fibroblasts with Hydroxyethyl Starch Nanomedicine Boosts Cancer Therapy about?

Cancer-associated fibroblasts (CAFs) play an important role in facilitating the progression of triple-negative breast cancer (TNBC) by deteriorating the tumor mechanical microenvironment (TMME). Herein, we designed a CAFs-targeting nanomedicine by conjugating doxorubicin (DOX)-loaded hydroxyethyl starch-IR780 nanoparticles (NPs) with Cys-Arg-Glu-Lys-Ala (CREKA) peptide, which had a special affinity for fibronectin overexpressed on CAFs. After systemic administration, the NPs efficiently targeted CAFs and generated hyperthermia upon light irradiation, decreasing CAFs through the combination of chemo-and photothermal-therapies. Thus, a series of changes in TMME were achieved by reducing CAFs, which further disrupted the niche of cancer stem cells (CSCs) to affect their survival. As a result, the tumor growth was significantly inhibited in 4T1 tumors. The strategy of TMME modulation and CSCs elimination through targeting and depleting CAFs provides a novel therapeutic treatment for desmoplastic solid tumors.

Who reads Targeting Cancer-associated Fibroblasts with Hydroxyethyl Starch Nanomedicine Boosts Cancer Therapy?

Author

Chong Wang; Huimin Wang; Hai Yang; Chen Xu; Qiang Wang; Zheng Li; Zhijie Zhang; Jiankun Guan; Ximiao Yu; Xiaoquan Yang; Xiangliang Yang; Zifu Li

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)