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Intake of the Major Carotenoids and the Risk of Epithelial Ovarian Cancer in a Pooled Analysis of 10 Cohort Studies by Anita Koushik; David J. Hunter; Donna Spiegelman; Kristin E. Anderson; Julie E. Buring; Jo L. Freudenheim; R. Alexandra Goldbohm; Susan E. Hankinson; Susanna C. Larsson; Michael Leitzmann; James R. Marshall; Marjorie L. McCullough; Anthony B. Miller; Carmen Rodriguez; Thomas E. Rohan; Julie A. Ross; Arthur Schatzkin; Leo J. Schouten; Walter C. Willett; Alicja Wolk; Shumin M. Zhang; Stephanie A. Smith‐Warner is a Medicine article available to read on EtoBox.

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## Abstract Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of α‐carotene, β‐carotene, β‐cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive epithelial ovarian cancer. The primary data from 10 prospective cohort studies in North America and Europe were analyzed and then pooled. Carotenoid intakes were estimated from a validated food frequency questionnaire administered at baseline in each study. Study‐specific relative risks (RR) were estimated using the Cox proportional hazards model and then combined using a random‐effects model. Among 521,911 women, 2,012 cases of ovarian cancer occurred during a follow‐up of 7–22 years across studies. The major carotenoids were not significantly associated with the risk of ovarian cancer. The pooled multivariate RRs (95% confidence intervals) were 1.00 (0.95–1.05) for a 600 μg/day increase in α‐carotene intake, 0.96 (0.93–1.03) for a 2,500 μg/day increase in β‐carotene intake, 0.99 (0.97–1.02) for a 100 μg/day increase in β‐cryptoxanthin i

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Author

Anita Koushik; David J. Hunter; Donna Spiegelman; Kristin E. Anderson; Julie E. Buring; Jo L. Freudenheim; R. Alexandra Goldbohm; Susan E. Hankinson; Susanna C. Larsson; Michael Leitzmann; James R. Marshall; Marjorie L. McCullough; Anthony B. Miller; Carmen Rodriguez; Thomas E. Rohan; Julie A. Ross; Arthur Schatzkin; Leo J. Schouten; Walter C. Willett; Alicja Wolk; Shumin M. Zhang; Stephanie A. Smith‐Warner

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2006

Language

EN

Field

Medicine (Health Sciences)