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Effect of Esketamine on Postpartum Depression After Labor Analgesia and Potential Mechanisms: a Randomized, Double-blinded Controlled Trial by Wei Wang; Bin Ling; Haibo Zhao; Jing He; Hua Xu; Jie Lv; Qi Wang is a Medicine article available to read on EtoBox.

What is Effect of Esketamine on Postpartum Depression After Labor Analgesia and Potential Mechanisms: a Randomized, Double-blinded Controlled Trial about?

## Abstract ## Background To evaluate the effect of esketamine combined with ropivacaine hydrochloride on the occurrence of postpartum depression (PPD) after labor analgesia under epidural analgesia pump and explore the possible mechanisms. ## Methods A total of 120 women aged 24 to 36 years old who underwent labor analgesia by epidural analgesia pump, with American Society of Anesthesiologists (ASA) physical status II were enrolled. According to the formula of epidural analgesia pump, all participants were randomly divided into two groups: esketamine group (Group E) and control group (Group C). Epidural anaesthesia were operated in all women between L~2~ and L~3~ after cervical dilation up to 2 ~ 3 cm. After successful puncture, the epidural catheter was placed 3.5 cm toward the head and 1% lidocaine was injected for 3 ml. The epidural analgesia pump was connected. Esketamine (0.2 mg/kg) combined with 0.75% ropivacaine hydrochloride (20 ml) were diluted by normal saline up to 100 ml in Group E, when only the equal dose of ropivacaine hydrochloride was used in Group C. The visual analogue scale (VAS) before analgesia (T~1~), 5 (T~2~), 10 (T~3~) and 20 (T~4~) minutes after analgesia

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Author

Wei Wang; Bin Ling; Haibo Zhao; Jing He; Hua Xu; Jie Lv; Qi Wang

Publisher

BioMed Central

Published

2024

Language

EN

Field

Medicine (Health Sciences)