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DRESS syndrome: case report A 20-year-old woman developed DRESS syndrome during treatment with sulfasalazine for ulcerative colitis. The woman, who had ulcerative colitis, started receiving sulfasalazine [dosage and route not stated]. Fourteen days after sulfasalazine initiation, she presented to the emergency department with a morbilliform, erythematous-violaceous rash, fever (38.5°C), lymphadenopathy, pruritus, myalgia and arthralgia. She was admitted to hospital. Exanthema appeared on her face and spread to the trunk and upper and lower extremities 4 days before admission, when she discontinued sulfasalazine on her own. PCR for SARS-CoV-2 was found to be positive. Her symptoms became more severe, with worsening liver function, lip erosion, facial and acral oedema, purple macules in the plantar regions and digital pulps. Laboratory examinations revealed the following: leucocytosis 28020 /μL, lymphocytosis 9807 /μL, 13% of atypical lymphocytes, eosinophilia 2522 /μL, elevated LDH 1378 U/L, elevated ESR, elevated C-reactive protein and elevated D dimers 1440 ng/mL. Transaminase levels were elevated to 7-fold the upper limit of normal (AST 350 iU/L and ALT 403 iU/L). Histopathologic

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Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)