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Identification of acid reflux cough using serial assays of exhaled breath condensate pH by John Hunt; Yuanlin Yu; James Burns; Benjamin Gaston; Lina Ngamtrakulpanit; Dorothy Bunyan; Brian K Walsh; Alison Smith; Stephanie Hom is a Medicine article available to read on EtoBox.

What is Identification of acid reflux cough using serial assays of exhaled breath condensate pH about?

## Background Chronic cough is a common problem, frequently caused or exacerbated by acid reflux. Diagnosis of acid reflux cough is haphazard currently, often relying on long therapeutic trials of expensive medications. We tested the hypothesis that the most relevant mechanistic component of acid reflux in chronic cough is when it rises to the level of the airway where acid can potentially be aspirated. We further wished to determine if multi-sample exhaled breath condensate (EBC) pH profiles can identify chronic cough patients likely to respond to proton pump inhibitor therapy. ## Methods 59 subjects were recruited for this study. Initially we examined EBC pH (gas-standardized with Argon) in the setting of 15 experimental pharyngeal acid challenges to determine duration of EBC acidification. Subsequently, we enrolled 22 healthy subjects to determine a normal multi-sample exhaled breath condensate pH profile over 1–3 days. We additionally obtained multi-sample EBC pH profiles in 22 patients with chronic cough. These samples were timed to occur after coughing episodes. Exhaled breath condensate pH was measured after gas standardization. ## Results We found that exhaled breath conden

Who reads Identification of acid reflux cough using serial assays of exhaled breath condensate pH?

Author

John Hunt; Yuanlin Yu; James Burns; Benjamin Gaston; Lina Ngamtrakulpanit; Dorothy Bunyan; Brian K Walsh; Alison Smith; Stephanie Hom

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: Biomed Central, 2005-2014.; Springer Science and Business Media LLC (ISSN 1745-9974)

Published

2006

Language

EN

ISBN

9781745997428

Field

Medicine (Health Sciences)