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What is Drug Biotransformation Pathways Explained about?

The document summarizes the key pathways of drug biotransformation in the body. It discusses phase I and phase II biotransformation. Phase I involves functional group transformation through oxidation, reduction and hydrolysis reactions catalyzed by cytochrome P450 enzymes. Phase II involves conjugation reactions that make the drug more polar via conjugation to glucuronic acid, sulfate, amino acids, acetyl groups, methyl groups, and glutathione. Common phase I reactions include aromatic hydroxylation, N-deal

Author

Javeria Ajaz

Language

EN